Compare Supplements

Side-by-side comparison of 2 supplements

Bbr7.5

Berberine

Moderate safety

Cgz4.5

Canagliflozin

Limited safety

Evidence

Likely helps

Evidence Score7.5/10

Studies: 108

Meta-analyses: 20

Mostly mechanism / observational

Evidence Score4.5/10

Studies: 7

Meta-analyses: 1

Dosage & timing

Dosage:

1200mg

Best Time:

With meals · with food

Take with food

Form:

Berberine HCl capsules

Dosage:

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Best Time:

Morning

Can take on empty stomach

Form:

Oral tablet (canagliflozin)

What you'll notice

📉 Lower Blood Sugarpositive

4-12 weeks

❤️ Improved Cholesterolpositive

8-12 weeks

🤢 GI Side Effectstrade-off

First 2 weeks

⏳ Lifespan extension (male mice)positive

Unknown in humans

❤️ Cardiovascular & kidney protectionpositive

Months to years

📉 Modest weight & BP reductionpositive

Weeks to months

Safety

Moderate safety

Contraindications:

Pregnancy and breastfeeding
Low blood pressure
Children

Drug Interactions:

Diabetes medications (metformin, insulin, etc.)
Blood pressure medications
CYP3A4 substrates (statins, calcium channel blockers, many medications)

Side Effects:

GI upset (cramping, diarrhea)ConstipationHeadache

Limited safety

Contraindications:

Type 1 diabetes (ketoacidosis risk)
Severe renal impairment / dialysis
History of recurrent diabetic ketoacidosis

Drug Interactions:

Diuretics
Insulin / sulfonylureas

Side Effects:

Genital yeast infectionVolume depletion / dizzinessEuglycemic diabetic ketoacidosis

Works well with

Probiotics

complementary

Bitter Melon

complementary

Cinnamon

complementary

No synergies listed

How they work together

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