Compare Supplements

Side-by-side comparison of 2 supplements

Bbr7.5

Berberine

Moderate safety

Dul7.0

Dulaglutide

Limited safety

Evidence

Likely helps

Evidence Score7.5/10

Studies: 108

Meta-analyses: 20

Mostly mechanism / observational

Evidence Score7/10

Studies: 12

Meta-analyses: 2

Dosage & timing

Dosage:

1200mg

Best Time:

With meals · with food

Take with food

Form:

Berberine HCl capsules

Dosage:

Prescription-only, clinician-prescribed. Subcutaneous 0.75 mg once weekly to start, usually escalated to 1.5 mg; 3.0 mg and 4.5 mg once-weekly doses are available for additional glycemic lowering. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly pen (Trulicity)

What you'll notice

📉 Lower Blood Sugarpositive

4-12 weeks

❤️ Improved Cholesterolpositive

8-12 weeks

🤢 GI Side Effectstrade-off

First 2 weeks

🩸 Improved glycemic controlpositive

Weeks to months

❤️ Reduced cardiovascular eventspositive

Months to years

⚖️ Modest weight losspositive

Months

Safety

Moderate safety

Contraindications:

Pregnancy and breastfeeding
Low blood pressure
Children

Drug Interactions:

Diabetes medications (metformin, insulin, etc.)
Blood pressure medications
CYP3A4 substrates (statins, calcium channel blockers, many medications)

Side Effects:

GI upset (cramping, diarrhea)ConstipationHeadache

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to dulaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrheaGallbladder disease (cholelithiasis / cholecystitis)

Works well with

Probiotics

complementary

Bitter Melon

complementary

Cinnamon

complementary

No synergies listed

How they work together

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