Compare Supplements

Side-by-side comparison of 2 supplements

Bbr9.0

Berberine

Moderate safety

Erg8.0

Ergothioneine

High safety

Evidence

Evidence Score9/10

Studies: 97

Meta-analyses: 20

Evidence Score8/10

Studies: 32

Meta-analyses: 2

Outcome Grades

Metabolic healthA

Healthy agingB

Reduce inflammationA

Metabolic healthC

Healthy agingB

Reduce inflammationC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

1200mg

Best Time:

With meals · with food

Take with food

Form:

Berberine HCl capsules

Dosage:

20mg

Best Time:

Any time · with food (preferred)

Can take on empty stomach

Form:

Synthetic L-ergothioneine capsules

What you'll notice

📉 Lower Blood Sugar80%

4-12 weeks

❤️ Improved Cholesterol65%

8-12 weeks

🤢 GI Side Effects35%

First 2 weeks

🛡️ Cellular Protection45%

Long-term

🧠 Cognitive Support35%

Long-term

Safety

Moderate safety

Contraindications:

Pregnancy and breastfeeding
Low blood pressure
Children

Drug Interactions:

Diabetes medications (metformin, insulin, etc.)
Blood pressure medications
CYP450 substrates (many medications)

Side Effects:

GI upset (cramping, diarrhea)ConstipationHeadache

High safety

Contraindications:

Known allergy or hypersensitivity to Ergothioneine or related compounds

Drug Interactions:

Gabapentin, pregabalin
Metformin
Chemotherapy drugs

Side Effects:

None established

Works well with

Probiotics

complementary

Bitter Melon

complementary

Lion's Mane

complementary

How they work together

Like what you see? Add these to your stack.

See how they work together through biological pathways.

Build Your Stack

Want to compare more supplements?

Loading comparison...