Compare Supplements

Side-by-side comparison of 2 supplements

Bi35.0

B. infantis 35624

High safety

Bla6.0

B. lactis (BB-12 / HN019)

High safety

Evidence

Mostly mechanism / observational

Evidence Score5/10

Studies: 13

Meta-analyses: 2

Mostly mechanism / observational

Evidence Score6/10

Studies: 23

Meta-analyses: 4

Outcome Verdicts

Improve digestionLikely helps

Improve digestionToo few graded studies

Plain-language verdict per shared outcome, pooled from the studies behind each supplement. Shows which one the evidence backs for the same goal.

Pooled effect-size head-to-headBeta

Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.

Outcome	B. infantis 35624	B. lactis (BB-12 / HN019)
Improve digestion — Ibs Severity − better · IBS-SSS points	−16.8best weak	−8.9 weak · CI ∋ 0

Click an outcome to see the full ranked table on the goal page.

Dosage & timing

Dosage:

1 x 10^8 CFU (100 million) daily — the dose that won the only head-to-head dose comparison; 1 x 10^10 CFU also beat placebo in a separate trial, so higher doses are not ruled out

Best Time:

Any time

Can take on empty stomach

Form:

Freeze-dried capsule standardized to 35624 at 1 x 10^8 CFU

Dosage:

1-10 billion CFU daily for BB-12 (1 billion is enough); 10-20 billion CFU daily for HN019 if transit is the goal

Best Time:

Any time · with food

Take with food

Form:

Capsule or sachet standardized to a named strain (BB-12 or HN019)

What you'll notice

🌀 Reduced IBS abdominal painpositive

4 weeks

🚽 Less straining during defecationpositive

4 weeks

⚖️ Bloating relief is not establishedneutral

n/a

⏱️ Faster whole-gut transitpositive

2 weeks

🚽 Slightly more frequent bowel movementspositive

4 weeks

🚫 Not a treatment for functional constipationnegative

n/a

Safety

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Lactulose breath testing

Side Effects:

Mild digestive upset

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Systemic antibiotics

Side Effects:

Mild transient digestive changes

Works well with

complementary

complementary

complementary

complementary

complementary

How they work together

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Outcome

B. infantis 35624

B. lactis (BB-12 / HN019)

Improve digestion — Ibs Severity

− better · IBS-SSS points

−16.8best

weak

−8.9

weak · CI ∋ 0