Compare Supplements

Side-by-side comparison of 2 supplements

Bla6.0

B. lactis (BB-12 / HN019)

High safety

Lp25.0

L. plantarum 299v

High safety

Evidence

Mostly mechanism / observational

Evidence Score6/10

Studies: 23

Meta-analyses: 4

Mostly mechanism / observational

Evidence Score5/10

Studies: 16

Meta-analyses: 2

Outcome Verdicts

Improve digestionToo few graded studies

Plain-language verdict per shared outcome, pooled from the studies behind each supplement. Shows which one the evidence backs for the same goal.

Pooled effect-size head-to-headBeta

Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.

Outcome	B. lactis (BB-12 / HN019)	L. plantarum 299v
Improve digestion — Ibs Severity − better · IBS-SSS points	−8.9 weak · CI ∋ 0	−32.6best weak

Click an outcome to see the full ranked table on the goal page.

Dosage & timing

Dosage:

1-10 billion CFU daily for BB-12 (1 billion is enough); 10-20 billion CFU daily for HN019 if transit is the goal

Best Time:

Any time · with food

Take with food

Form:

Capsule or sachet standardized to a named strain (BB-12 or HN019)

Dosage:

1 x 10^9 CFU (1 billion) daily taken WITH the iron-containing meal is sufficient for the iron effect — in the dual-isotope crossover trial 10^9 was significant (28.6% vs 18.5%, p<0.028) while 10^10 was NOT (29.1% vs 20.1%, p=0.080). The freeze-dried capsule and IBS trials used 1 x 10^10 CFU daily, and the pregnancy trial used 1 x 10^10 CFU twice daily (2 x 10^10 CFU/day)

Best Time:

With meals · with food

Take with food

Form:

Freeze-dried capsule standardized to 299v (DSM 9843)

What you'll notice

⏱️ Faster whole-gut transitpositive

2 weeks

🚽 Slightly more frequent bowel movementspositive

4 weeks

🚫 Not a treatment for functional constipationnegative

n/a

🧲 Better iron absorption from the same mealpositive

Immediate, per meal

🤰 Better iron status in pregnancypositive

12-25 weeks

🌀 IBS pain and bloating relief (low certainty)neutral

4 weeks

Safety

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Systemic antibiotics

Side Effects:

Mild transient digestive changes

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter
Short-bowel syndrome or compromised gut barrier

Drug Interactions: