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Plain-language verdict per shared outcome, pooled from the studies behind each supplement. Shows which one the evidence backs for the same goal.
Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.
| Outcome | B. lactis (BB-12 / HN019) | VSL#3 / Visbiome |
|---|---|---|
| Improve digestion — Ibs Severity − better · IBS-SSS points | −8.9 weak · CI ∋ 0 | −98.1 weak · CI ∋ 0 |
1-10 billion CFU daily for BB-12 (1 billion is enough); 10-20 billion CFU daily for HN019 if transit is the goal
Any time · with food
Capsule or sachet standardized to a named strain (BB-12 or HN019)
Prevention and maintenance are DIFFERENT doses and are often conflated. Preventing the first onset of acute pouchitis used 900 billion CFU/day (1 sachet). Maintaining remission in established chronic or refractory pouchitis — where the effect size is largest — used 6 g/day, which at 5 x 10^11 viable bacteria per gram is about 3 trillion CFU/day, in both maintenance trials. As a ulcerative colitis add-on, 3.6 trillion CFU daily; the active-UC induction trial went highest at 3.6 trillion CFU TWICE daily (7.2 trillion/day), and the paediatric trial lowest at 450 billion/day weight-based
Any time
Refrigerated sachet of the De Simone Formulation
2 weeks
4 weeks
n/a
9-12 months
12 months
8-12 weeks
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