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1 x 10^9 to 1 x 10^10 CFU daily — the two trials that state a dose used 1 x 10^10 CFU/day (depression) and a minimum of 1 x 10^9 CFU/day (pregnancy). Neither found a benefit on its primary endpoint, so this is the dose range that has been tested, not a dose shown to work.

Any time

Freeze-dried capsule or sachet standardized to B. longum 1714

20billion CFU

Morning

Capsules with multiple strains

• Immunocompromise or immunosuppression (class-level precaution for live probiotics)
• Critical illness or indwelling central venous catheter

• Systemic antibiotics
• Immunosuppressants

• Severely immunocompromised individuals
• Central venous catheters
• Severe acute pancreatitis

• Antibiotics
• Immunosuppressants