Compare Supplements

Side-by-side comparison of 2 supplements

But4.5

Butyrate

High safety

Tbu2.0

Tributyrin

Moderate safety

Evidence

Likely helps

Evidence Score4.5/10

Studies: 80

Meta-analyses: 6

Mostly mechanism / observational

Evidence ScoreNot scored

Studies: 10

Meta-analyses: 0

Dosage & timing

Dosage:

1200mg

Best Time:

With meals · with food

Take with food

Form:

Enteric-coated sodium or calcium butyrate

Dosage:

500 mg three times daily (1.5 g/day) — the only supplement-realistic dose ever tested in humans, used in the 30-day open-label Parkinson's study. Three times daily is not optional: plasma butyrate is gone by 5 hours after a dose, which is precisely why the second Phase I study abandoned once-daily dosing

Best Time:

Split through the day

Can take on empty stomach

Form:

Plain oral tributyrin, dosed three times daily

What you'll notice

✨ Gut Healingpositive

2-4 weeks

🔥 Reduced Gut Inflammationpositive

4-8 weeks

📈 Raises plasma butyrate, brieflypositive

Within hours

🚫 No efficacy endpoint has ever been metnegative

n/a

🚫 Distal-colonic delivery is not demonstratednegative

n/a

Safety

High safety

Contraindications:

Known allergy or hypersensitivity to Butyrate or related compounds

Side Effects:

GI discomfortSulfur-like odor

Moderate safety

Contraindications:

None established — but note that no safety study has ever run longer than 30 days at supplement doses

Drug Interactions:

Calcitriol / active vitamin D (cell-culture finding only)

Side Effects:

Odour (on breath, skin or stool)Nausea, abdominal cramping and diarrhoeaVomiting and myalgia

Works well with

complementary

complementary

complementary

complementary

How they work together

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