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Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (canagliflozin)

Off-label longevity use mirrors low antihypertensive dosing (captopril is short-acting; longer-acting ACE inhibitors like lisinopril/ramipril are often used) under a clinician. Not an approved longevity regimen; blood pressure and potassium should be monitored.

Any time

Oral tablet (or a longer-acting ACE inhibitor)

• Type 1 diabetes (ketoacidosis risk)
• Severe renal impairment / dialysis
• History of recurrent diabetic ketoacidosis

• Diuretics
• Insulin / sulfonylureas

• Pregnancy (fetal harm)
• History of ACE-inhibitor angioedema
• Bilateral renal artery stenosis

• Potassium-sparing diuretics / potassium / salt substitutes
• NSAIDs
• Lithium