Compare Supplements

Side-by-side comparison of 2 supplements

Cgz4.5

Canagliflozin

Limited safety

Dul7.0

Dulaglutide

Limited safety

Evidence

Mostly mechanism / observational

Evidence Score4.5/10

Studies: 7

Meta-analyses: 1

Mostly mechanism / observational

Evidence Score7/10

Studies: 12

Meta-analyses: 2

Dosage & timing

Dosage:

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Best Time:

Morning

Can take on empty stomach

Form:

Oral tablet (canagliflozin)

Dosage:

Prescription-only, clinician-prescribed. Subcutaneous 0.75 mg once weekly to start, usually escalated to 1.5 mg; 3.0 mg and 4.5 mg once-weekly doses are available for additional glycemic lowering. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly pen (Trulicity)

What you'll notice

⏳ Lifespan extension (male mice)positive

Unknown in humans

❤️ Cardiovascular & kidney protectionpositive

Months to years

📉 Modest weight & BP reductionpositive

Weeks to months

🩸 Improved glycemic controlpositive

Weeks to months

❤️ Reduced cardiovascular eventspositive

Months to years

⚖️ Modest weight losspositive

Months

Safety

Limited safety

Contraindications:

Type 1 diabetes (ketoacidosis risk)
Severe renal impairment / dialysis
History of recurrent diabetic ketoacidosis

Drug Interactions:

Diuretics
Insulin / sulfonylureas

Side Effects:

Genital yeast infectionVolume depletion / dizzinessEuglycemic diabetic ketoacidosis

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to dulaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrheaGallbladder disease (cholelithiasis / cholecystitis)

How they work together

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