Compare Supplements

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (canagliflozin)

Standard approved dosing is 140 mg subcutaneously every 2 weeks OR 420 mg subcutaneously once monthly, under a clinician. A prescription drug; this is informational, not a recommendation.

Any time

Subcutaneous prefilled autoinjector (evolocumab)

• Type 1 diabetes (ketoacidosis risk)
• Severe renal impairment / dialysis
• History of recurrent diabetic ketoacidosis

• Diuretics
• Insulin / sulfonylureas

• Prior serious hypersensitivity reaction to evolocumab
• Use only under clinician direction as part of a lipid-management plan

• Statins
• Ezetimibe