Compare Supplements

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (canagliflozin)

Prescription Xenical: 120 mg three times daily (360 mg/day), taken with or up to 1 hour after each main fat-containing meal. Over-the-counter Alli: 60 mg three times daily (180 mg/day). Skip the dose if a meal is missed or contains no fat. Used alongside a reduced-calorie diet in which fat supplies roughly 30% of energy — a higher-fat meal makes the gastrointestinal side effects markedly worse, not the weight loss better.

With meals · with food

Xenical 120 mg capsule three times daily with meals (prescription)

• Type 1 diabetes (ketoacidosis risk)
• Severe renal impairment / dialysis
• History of recurrent diabetic ketoacidosis

• Diuretics
• Insulin / sulfonylureas

• Chronic malabsorption syndrome
• Cholestasis
• Pregnancy — intentional weight loss is not a therapeutic goal in pregnancy, and orlistat measurably lowers vitamin D and impairs vitamin E and K absorption (McDuffie 2002)

• Warfarin
• Levothyroxine (thyroxine)
• Ciclosporin (cyclosporine)