Compare Supplements

Off-label use mirrors diabetes dosing (e.g. 100–300 mg once daily before the first meal) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (canagliflozin)

Off-label metabolic use mirrors diabetes dosing (e.g. 15–45 mg once daily) under a clinician. A prescription drug; not an approved longevity regimen.

Morning

Oral tablet (pioglitazone)

• Type 1 diabetes (ketoacidosis risk)
• Severe renal impairment / dialysis
• History of recurrent diabetic ketoacidosis

• Diuretics
• Insulin / sulfonylureas

• Symptomatic heart failure (NYHA III–IV)
• Active or history of bladder cancer
• Active liver disease / significant hepatic impairment

• Insulin
• Gemfibrozil (CYP2C8 inhibitor)
• Insulin secretagogues (sulfonylureas)