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A prescription biologic, not self-administered for longevity. Approved CAPS dosing is 150 mg subcutaneously every 8 weeks (weight-adjusted in children). The CANTOS cardiovascular regimen was 150 mg subcutaneously every 3 months. There is NO established off-label longevity protocol, and cost is prohibitive.

Any time

Subcutaneous injection (clinician-administered)

500mg

Morning · with food (preferred)

Nicotinamide Riboside Chloride capsules or powder

• Active or chronic infection
• Live vaccines during treatment
• Known hypersensitivity to canakinumab

• Other immunosuppressants / biologics (e.g. TNF inhibitors)
• Live vaccines

• Known hypersensitivity to nicotinamide riboside or niacin derivatives
• Active cancer or cancer history: NAD+ elevation may theoretically support tumor cell metabolism (consult oncologist before use)
• Severe hepatic impairment: high-dose NAD+ precursors may affect liver metabolism

• Chemotherapy agents
• PARP inhibitors (e.g., olaparib, niraparib)
• Alcohol