Compare Supplements

Side-by-side comparison of 2 supplements

Can4.0

Canakinumab

Limited safety

Ryr7.8

Red Yeast Rice

Limited safety

Evidence

Mostly mechanism / observational

Evidence Score4/10

Studies: 6

Meta-analyses: 1

Likely helps

Evidence Score7.8/10

Studies: 51

Meta-analyses: 14

Dosage & timing

Dosage:

A prescription biologic, not self-administered for longevity. Approved CAPS dosing is 150 mg subcutaneously every 8 weeks (weight-adjusted in children). The CANTOS cardiovascular regimen was 150 mg subcutaneously every 3 months. There is NO established off-label longevity protocol, and cost is prohibitive.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous injection (clinician-administered)

Dosage:

10mg monacolin K

Best Time:

Evening · with food

Take with food

Form:

Standardized extract with verified monacolin K content

What you'll notice

❤️ Reduced cardiovascular eventspositive

Months to years

🔥 Lowered inflammationpositive

Weeks

ℹ️ No survival benefitneutral

Trial endpoints

📉 LDL Reductionpositive

8-12 weeks

📊 Total Cholesterol Reductionpositive

8-12 weeks

Safety

Limited safety

Contraindications:

Active or chronic infection
Live vaccines during treatment
Known hypersensitivity to canakinumab

Drug Interactions:

Other immunosuppressants / biologics (e.g. TNF inhibitors)
Live vaccines

Side Effects:

Infections (including upper respiratory and injection-site)Neutropenia / injection-site reactionsSerious / fatal infection

Limited safety

Contraindications:

Liver disease
Pregnancy/nursing
History of statin intolerance

Drug Interactions:

Statins
Grapefruit
Fibrates

Side Effects:

Muscle pain/weaknessGI upsetLiver enzyme elevation

Works well with

No synergies listed

CoQ10

enhances

Omega-3

complementary

Pantethine

complementary

How they work together

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