We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Pantethine (Vitamin B5 derivative)
The active disulfide form of vitamin B5 (pantothenic acid) with older human and mechanistic evidence for modestly lowering LDL/triglycerides and raising HDL — better-studied for lipids than plain pantothenic acid, but the human trial base is dated and small.
What the evidence says
Most Pantethine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 1982–2023 with a typical study size of 32 participants.
Based on 5 studies · 1 RCT · 32 total participants
Confidence
LowBy outcome
Pantethine has an evidence score of 4/10 — emerging evidence based on 5 indexed studies. The active disulfide form of vitamin B5 (pantothenic acid) with older human and mechanistic evidence for modestly lowering LDL/triglycerides and raising HDL — better-studied for lipids than plain pantothenic acid, but the human trial base is dated and small. Representative study: PMID 24600231.
The commonly studied dose of Pantethine is 600-900mg pantethine daily, split. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
See full supplement plans that include Pantethine.
Explore: Best supplements for Vitality & Longevity
Last reviewed June 2026 · evidence from 5 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Pantethine is the disulfide dimer of pantetheine, the active metabolite of vitamin B5 (pantothenic acid) and a precursor of coenzyme A. Unlike plain pantothenic acid, pantethine has a lipid-modifying reputation: older human studies and a small modern RCT report modest reductions in LDL cholesterol and triglycerides with a rise in HDL, via effects on cholesterol/fatty-acid synthesis (CoA pathway). The honest picture: much of the human evidence is dated and from small trials, and mechanistic support is largely cell/animal — so it's a modestly-evidenced lipid adjunct, not a statin substitute.
Pantethine feeds CoA, central to lipid and energy metabolism.
Modulates cholesterol and fatty-acid synthesis enzymes.
How Pantethine works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
600-900mg pantethine daily, split
Take with food
| Form | Type |
|---|---|
| 💊Pantethine (600-900mg) | Recommended |
| 💊Pantothenic acid (different, less lipid effect) | Alternative |
Pantethine ≠ plain B5 for lipids.
Compare Pantethine vs Pantothenic Acid →Minimum: 8 weeks
Optimal: 16 weeks
Cycling: Not required
Note: Split doses with meals.
Dose-response data unavailable. The current published research for Pantethine does not provide sufficient dose-specific outcome data to generate reliable dose-response curves.
Refer to the Dosage & Timing section above for recommended dose ranges based on available evidence.
Modestly reduces LDL and triglycerides.
May raise HDL cholesterol.
Food-level B5 fine; supplemental pantethine not well studied.
Additive lipid effect — generally complementary; inform your clinician.
Tip: Take with food; split doses
The best time to take Pantethine is with meals. Take it with food. Taken with meals, split into 2-3 doses; lipid effects build over months.
Pantethine is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset/nausea. Use caution if any of these apply to you: Pregnancy/breastfeeding (supplemental doses not well studied).
Enhances mitochondrial energy production and acts as a lipid-soluble antioxidant — critical for heart health and depleted by statins.
Tap node to isolate • Pinch to zoom • Tap edge for research