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Off-label longevity use mirrors low antihypertensive dosing (captopril is short-acting; longer-acting ACE inhibitors like lisinopril/ramipril are often used) under a clinician. Not an approved longevity regimen; blood pressure and potassium should be monitored.
Any time
Oral tablet (or a longer-acting ACE inhibitor)
Off-label use mirrors approved dosing (10–25 mg once daily in the morning) under a clinician. A prescription drug; not an approved longevity regimen.
Morning
Oral tablet (empagliflozin)
Unknown in humans
Months to years
Years
Months to years
Months to years
Weeks to months
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