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Off-label longevity use mirrors low antihypertensive dosing (captopril is short-acting; longer-acting ACE inhibitors like lisinopril/ramipril are often used) under a clinician. Not an approved longevity regimen; blood pressure and potassium should be monitored.

Any time

Oral tablet (or a longer-acting ACE inhibitor)

Standard approved dosing is 140 mg subcutaneously every 2 weeks OR 420 mg subcutaneously once monthly, under a clinician. A prescription drug; this is informational, not a recommendation.

Any time

Subcutaneous prefilled autoinjector (evolocumab)

• Pregnancy (fetal harm)
• History of ACE-inhibitor angioedema
• Bilateral renal artery stenosis

• Potassium-sparing diuretics / potassium / salt substitutes
• NSAIDs
• Lithium

• Prior serious hypersensitivity reaction to evolocumab
• Use only under clinician direction as part of a lipid-management plan

• Statins
• Ezetimibe