Compare Supplements

Side-by-side comparison of 2 supplements

Cpt3.5

Captopril

Limited safety

MtQ5.0

MitoQ

High safety

Evidence

Mostly mechanism / observational

Evidence Score3.5/10

Studies: 5

Meta-analyses: 0

Mostly mechanism / observational

Evidence Score5/10

Studies: 7

Meta-analyses: 0

Dosage & timing

Dosage:

Off-label longevity use mirrors low antihypertensive dosing (captopril is short-acting; longer-acting ACE inhibitors like lisinopril/ramipril are often used) under a clinician. Not an approved longevity regimen; blood pressure and potassium should be monitored.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (or a longer-acting ACE inhibitor)

Dosage:

10-20mg daily

Best Time:

Morning

Can take on empty stomach

Form:

Oral capsule (mitoquinol mesylate, 10-20 mg)

What you'll notice

⏳ Lifespan extension (model organisms)positive

Unknown in humans

❤️ Cardiovascular mortality benefitpositive

Months to years

🫘 Kidney protectionpositive

Years

🩸 Improved Endothelial Functionpositive

Acute to 6 weeks

🫁 Lowered Liver Enzymespositive

4 weeks

🧠 No Effect on Parkinson'sneutral

12 months

Safety

Limited safety

Contraindications:

Pregnancy (fetal harm)
History of ACE-inhibitor angioedema
Bilateral renal artery stenosis

Drug Interactions:

Potassium-sparing diuretics / potassium / salt substitutes
NSAIDs
Lithium

Side Effects:

Dry coughHyperkalemiaAngioedema

High safety

Contraindications:

None established at studied doses; consult a clinician if pregnant, nursing, or on the medications below

Drug Interactions:

Blood pressure medications
Anticoagulants (warfarin)

Side Effects:

GI upset / abdominal discomfortHeadache

Works well with

No synergies listed

CoQ10

complementary

Urolithin A

complementary

NMN

complementary

How they work together

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