Compare Supplements

1000-6000mg (1-6g) cinnamon powder daily, or 250-500mg standardized extract; prefer Ceylon for regular use

With meals · with food (preferred)

Ceylon cinnamon powder or standardized aqueous extract

INVESTIGATIONAL — NO approved or consumer dose. In trials, efpeglenatide was given as a once-weekly subcutaneous injection, titrated up to 4-6 mg (AMPLITUDE-O used 4 and 6 mg) with gradual escalation to limit GI side effects. Not for self-administration; it is an unapproved, unmarketed investigational drug.

Any time

Once-weekly subcutaneous injection (investigational only)

• Liver disease (especially with high-coumarin Cassia)
• Known cinnamon or balsam of Peru allergy

• Diabetes medications (insulin, sulfonylureas, metformin)
• Anticoagulants/antiplatelets (warfarin)
• Hepatotoxic drugs

• Not a dietary supplement and not an approved/marketed drug — investigational; do not self-source grey-market vials
• Personal/family history of medullary thyroid carcinoma or MEN 2 (expected GLP-1-class thyroid C-cell warning)
• History of pancreatitis

• Oral medications (delayed gastric emptying)
• Insulin / insulin secretagogues (sulfonylureas)
• Other GLP-1 / incretin drugs