Compare Supplements

Side-by-side comparison of 2 supplements

Cin6.8

Cinnamon

Moderate safety

Sgl8.5

Semaglutide

Limited safety

Evidence

Mostly mechanism / observational

Evidence Score6.8/10

Studies: 35

Meta-analyses: 15

Mostly mechanism / observational

Evidence Score8.5/10

Studies: 36

Meta-analyses: 2

Dosage & timing

Dosage:

1000-6000mg (1-6g) cinnamon powder daily, or 250-500mg standardized extract; prefer Ceylon for regular use

Best Time:

With meals · with food (preferred)

Take with food

Form:

Ceylon cinnamon powder or standardized aqueous extract

Dosage:

Prescription-only, clinician-titrated. Subcutaneous (Wegovy weight management: escalate to 2.4 mg once weekly; Ozempic diabetes: 0.5-2.0 mg once weekly). Oral (Rybelsus diabetes: 3-14 mg once daily). DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly injection (Ozempic / Wegovy)

What you'll notice

🩸 Lower fasting blood glucosepositive

4-12 weeks

🔑 Improved insulin sensitivitypositive

4-12 weeks

❤️ Improved blood lipidspositive

8-12 weeks

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Substantial weight losspositive

Months (titrated over 16-20 weeks)

❤️ Reduced cardiovascular eventspositive

Months to years

Safety

Moderate safety

Contraindications:

Liver disease (especially with high-coumarin Cassia)
Known cinnamon or balsam of Peru allergy

Drug Interactions:

Diabetes medications (insulin, sulfonylureas, metformin)
Anticoagulants/antiplatelets (warfarin)
Hepatotoxic drugs

Side Effects:

Mild GI upset / heartburnMouth irritation (with powder)Liver enzyme elevation (high-dose Cassia, coumarin)

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to semaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrhea / constipationGallbladder disease (cholelithiasis / cholecystitis)

Works well with

Chromium

complementary

Berberine

complementary

Alpha-Lipoic Acid

complementary

No synergies listed

How they work together

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