Compare Supplements

Off-label (male) / approved (female) — clinician-directed. For female ovulation induction the approved regimen is 50 mg once daily for 5 days starting early in the cycle, titrated up to 100-150 mg if needed. For off-label male hypogonadism, observational studies used roughly 25-50 mg daily or every other day (25 mg/day is the most common starting dose), titrated to testosterone and LH/FSH response. There is no FDA-approved male dose.

Any time

Clomiphene citrate tablets (racemic — approved for women; off-label in men)

Prescription-only and indication-dependent. For fertility preservation / intratesticular-testosterone maintenance on TRT, small studies used ~125-500 IU subcutaneously every other day. For spermatogenesis induction in hypogonadotropic hypogonadism, typically ~1,000-2,500 IU two to three times weekly (often combined with FSH), titrated to response. For female ovulation/oocyte-maturation trigger, a single dose (~5,000-10,000 IU urinary or 250 µg recombinant). No dietary-supplement dose exists.

Any time

Prescription hCG — recombinant (choriogonadotropin alfa) or urinary-derived, by injection

• Pregnancy (clomiphene is contraindicated once pregnancy is established)
• Liver disease, undiagnosed abnormal uterine bleeding, or ovarian cysts not due to PCOS (per the approved female label)
• Primary (testicular) hypogonadism in men — needs an intact pituitary/testis axis to work

• Exogenous testosterone / anabolic steroids
• Aromatase inhibitors / other SERMs (e.g. tamoxifen, letrozole)
• Estrogens

• Hormone-sensitive tumors (e.g. prostate, breast) or other androgen/estrogen-dependent conditions
• Known hypersensitivity to hCG
• Use without medical supervision

• Exogenous testosterone / anabolic steroids
• FSH / hMG (menotropins)
• Aromatase inhibitors (e.g. anastrozole)