Compare Supplements

Side-by-side comparison of 2 supplements

Col6.0

Collagen

High safety

Mtx3.0

Matrixyl

High safety

Evidence

Evidence Score6/10

Studies: 51

Meta-analyses: 4

Evidence Score3/10

Studies: 6

Meta-analyses: 0

Outcome Grades

Skin firmness & elasticityC

Reduce wrinkles & fine linesC

Skin firmness & elasticityD

Reduce wrinkles & fine linesD

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

15g

Best Time:

Any time · with food (preferred)

Can take on empty stomach

Form:

Hydrolyzed collagen peptides (powder)

Dosage:

Topical cosmetic only. Matrixyl (palmitoyl pentapeptide-4 / pal-KTTKS, or the Matrixyl 3000 blend of palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7) is used at very low concentrations in leave-on serums and creams — clinical benefit was shown at as little as 3 ppm pal-KTTKS, and consumer products commonly list 3-10% of the branded blend. Applied to the target area once or twice daily. There is no oral, injectable, or systemic dose — it is not ingested.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical cosmetic (serum or cream) containing palmitoyl pentapeptide-4 or the Matrixyl 3000 blend

What you'll notice

✨ Improved Skin Elasticitypositive

8-12 weeks

🦵 Reduced Joint Painpositive

8-12 weeks

💅 Stronger Nailspositive

12 weeks

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🧵 Reduced appearance of fine lines (small trials)positive

8-12 weeks

🔬 Stimulates collagen/ECM genes (in vitro)neutral

Cell studies

Safety

High safety

Contraindications:

Allergy to source (fish, shellfish, eggs, beef)
Phenylketonuria (some products contain phenylalanine)

Drug Interactions:

No significant interactions known

Side Effects:

Feeling of fullnessDigestive discomfortBad taste (some products)

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection
Known allergy or sensitivity to the peptide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Other topical actives (retinoids, acids)

Side Effects:

Local skin irritation or rednessContact allergic reaction

Works well with

Vitamin C

enhances

Glucosamine

complementary

Biotin

complementary

No synergies listed

How they work together

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