Compare Supplements

Side-by-side comparison of 2 supplements

Ct9.5

Creatine

High safety

Mdf5.0

Modafinil

Limited safety

Evidence

Evidence Score9.5/10

Studies: 85

Meta-analyses: 17

Evidence Score5/10

Studies: 7

Meta-analyses: 2

Dosage & timing

Dosage:

Best Time:

Any time · with food (preferred)

Can take on empty stomach

Form:

Monohydrate powder

Dosage:

Approved dosing is 200 mg once daily in the morning for narcolepsy and OSA, or 200 mg taken ~1 hour before the start of a night shift for shift-work sleep disorder. A prescription drug; off-label cognitive use is not an approved or standardized regimen.

Best Time:

Morning

Can take on empty stomach

Form:

Oral tablet (modafinil)

What you'll notice

💪 Increased Strengthpositive

2-4 weeks

📈 Muscle Fullnesspositive

1-2 weeks

💧 Water Retentiontrade-off

First week

⚡ Reduced excessive sleepinesspositive

Hours (per dose); weeks for steady benefit

🧠 Modest cognitive enhancementpositive

Per dose (acute)

📉 Small effect in healthy usersneutral

Acute

Safety

High safety

Contraindications:

Pre-existing kidney disease (consult doctor)
Rare genetic creatine metabolism disorders

Drug Interactions:

Nephrotoxic drugs

Side Effects:

Water retentionGI discomfort

Limited safety

Contraindications:

Prior hypersensitivity or serious skin reaction to modafinil/armodafinil
History of left ventricular hypertrophy or mitral valve prolapse with prior stimulant use
Uncontrolled hypertension or arrhythmia (use with caution)

Drug Interactions:

Hormonal contraceptives
Warfarin / CYP2C19 substrates
MAO inhibitors / other stimulants

Side Effects:

HeadacheInsomnia / anxiety / nervousnessSerious skin reaction (Stevens-Johnson syndrome / TEN)

Works well with

Beta-Alanine

complementary

Beetroot

complementary

Beta-Ecdysterone

complementary

No synergies listed

How they work together

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