Compare Supplements

Side-by-side comparison of 2 supplements

Cur7.5

Curcumin

High safety

Thc2.5

Tetrahydrocurcumin

Moderate safety

Evidence

Likely helps

Evidence Score7.5/10

Studies: 464

Meta-analyses: 24

Mostly mechanism / observational

Evidence ScoreNot scored

Studies: 13

Meta-analyses: 0

Dosage & timing

Dosage:

1500mg

Best Time:

With meals · with food

Take with food

Form:

Enhanced absorption form: Longvida, Meriva, or BCM-95

Dosage:

No established human dose. The one oral human pilot used 200 mg/day; supplement products typically supply 250–500 mg/day. Dosing is not evidence-based.

Best Time:

Any time · with food

Take with food

Form:

Oral tetrahydrocurcumin capsule

What you'll notice

🔥 Lower Inflammationpositive

4-8 weeks

🦵 Joint Comfortpositive

4-8 weeks

😊 Better Moodpositive

4-8 weeks

🛡️ Antioxidant support (preclinical)positive

Unknown in humans

🔥 Anti-inflammatory activity (preclinical)positive

Unknown in humans

🧠 Possible antidepressant adjunct (pilot only)neutral

~4 weeks (single pilot)

Safety

High safety

Contraindications:

Gallbladder disease
Bleeding disorders
Scheduled surgery (stop 2 weeks before)

Drug Interactions:

Blood thinners
Diabetes medications
Iron supplements

Side Effects:

GI upsetHeadache

Moderate safety

Contraindications:

Pregnancy and breastfeeding (no safety data)
Bleeding disorders or scheduled surgery (theoretical antiplatelet effect, by analogy to curcumin)

Drug Interactions:

Anticoagulants / antiplatelets
Antidiabetic drugs
CYP / P-glycoprotein substrates

Side Effects:

GI upsetUnknown long-term effects

Works well with

Omega-3

enhances

Ginger Extract

complementary

Black Pepper Extract

complementary

No synergies listed

How they work together

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