Compare Supplements

Side-by-side comparison of 2 supplements

Dap4.4

Dapagliflozin

Limited safety

Los4.2

Losartan

Limited safety

Evidence

Mostly mechanism / observational

Evidence Score4.4/10

Studies: 6

Meta-analyses: 1

Mostly mechanism / observational

Evidence Score4.2/10

Studies: 7

Meta-analyses: 0

Dosage & timing

Dosage:

Off-label use mirrors approved dosing (10 mg once daily) under a clinician. A prescription drug; not an approved longevity regimen.

Best Time:

Morning

Can take on empty stomach

Form:

Oral tablet (dapagliflozin)

Dosage:

Off-label longevity/muscle-aging use mirrors low antihypertensive dosing (25–100 mg once daily) under a clinician. Not an approved longevity or anti-sarcopenia regimen; blood pressure, kidney function, and potassium should be monitored.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (losartan potassium)

What you'll notice

🫀 Heart-failure protectionpositive

Months to years

❤️ Kidney protectionpositive

Months to years

📉 Modest weight & BP reductionpositive

Weeks to months

🧠 Stroke / cardiovascular preventionpositive

Months to years

🫘 Diabetic kidney protectionpositive

Years

💪 Muscle repair / anti-atrophy (animal only)positive

Unknown in humans

Safety

Limited safety

Contraindications:

Type 1 diabetes (ketoacidosis risk)
Severe renal impairment per label / dialysis
History of recurrent diabetic ketoacidosis

Drug Interactions:

Diuretics
Insulin / sulfonylureas

Side Effects:

Genital yeast infectionVolume depletion / dizzinessEuglycemic diabetic ketoacidosis

Limited safety

Contraindications:

Pregnancy (fetal harm)
Bilateral renal artery stenosis
Hyperkalemia

Drug Interactions:

Potassium-sparing diuretics / potassium / salt substitutes
NSAIDs
Lithium

Side Effects:

Dizziness / hypotensionHyperkalemiaAngioedema

How they work together

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