Compare Supplements

1-2 capsules with meals (varies by product)

With meals · with food

Broad-spectrum enzyme blend capsules

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Any time

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

• Active ulcers or gastritis (some enzymes may irritate)
• Allergy to source (pineapple for bromelain, papaya for papain)

• Blood thinners
• Diabetes medications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple endocrine neoplasia syndrome type 2 (MEN2)
• History of pancreatitis (use with caution / avoid)

• Oral contraceptives
• Insulin and sulfonylureas
• Oral medications generally