Compare Supplements

Side-by-side comparison of 2 supplements

Emp4.5

Empagliflozin

Limited safety

NR5.5

Nicotinamide Riboside

High safety

Evidence

Mostly mechanism / observational

Evidence Score4.5/10

Studies: 7

Meta-analyses: 1

Mostly mechanism / observational

Evidence Score5.5/10

Studies: 37

Meta-analyses: 1

Dosage & timing

Dosage:

Off-label use mirrors approved dosing (10–25 mg once daily in the morning) under a clinician. A prescription drug; not an approved longevity regimen.

Best Time:

Morning

Can take on empty stomach

Form:

Oral tablet (empagliflozin)

Dosage:

500mg

Best Time:

Morning · with food (preferred)

Take with food

Form:

Nicotinamide Riboside Chloride capsules or powder

What you'll notice

❤️ Reduced cardiovascular deathpositive

Months to years

🫀 Heart-failure & kidney protectionpositive

Months to years

📉 Modest weight & BP reductionpositive

Weeks to months

📈 Elevated Blood NAD+ Levelspositive

1–2 weeks

⚡ Energy & Fatigue (Unproven)neutral

4–8 weeks

🧠 No Measured Cognitive Gainneutral

8–16 weeks

Safety

Limited safety

Contraindications:

Type 1 diabetes (ketoacidosis risk)
Severe renal impairment per label / dialysis
History of recurrent diabetic ketoacidosis

Drug Interactions:

Diuretics
Insulin / sulfonylureas

Side Effects:

Genital yeast infectionVolume depletion / dizzinessEuglycemic diabetic ketoacidosis

High safety

Contraindications:

Known hypersensitivity to nicotinamide riboside or niacin derivatives
Active cancer or cancer history: NAD+ elevation may theoretically support tumor cell metabolism (consult oncologist before use)
Severe hepatic impairment: high-dose NAD+ precursors may affect liver metabolism

Drug Interactions:

Chemotherapy agents
PARP inhibitors (e.g., olaparib, niraparib)
Alcohol

Side Effects:

NauseaHeadacheBloating or GI discomfort

Works well with

No synergies listed

Pterostilbene

enhances

Resveratrol

complementary

CoQ10

complementary

How they work together

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