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No validated longevity dose. Geroscience trials used low intermittent dosing (e.g. ~0.5 mg/day or ~5 mg/week of RAD001) — unproven and not an approved regimen. Approved oncology dosing is 10 mg/day (Afinitor) and transplant dosing is trough-titrated (Zortress); both are far higher than any longevity protocol.
Any time
Oral everolimus tablet
No validated longevity dose. Off-label protocols use intermittent low doses (e.g. ~5–6 mg once weekly) under physician supervision — this is unproven and not an approved regimen. Approved transplant dosing is daily and immunosuppressive.
Any time
Oral sirolimus tablet/solution
Weeks to months
Months
Throughout use
Unknown in humans
Weeks
Throughout use
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