Compare Supplements

Standard approved dosing is 140 mg subcutaneously every 2 weeks OR 420 mg subcutaneously once monthly, under a clinician. A prescription drug; this is informational, not a recommendation.

Any time

Subcutaneous prefilled autoinjector (evolocumab)

Approved dose is 2 g twice daily (4 g/day total) taken with food, under a clinician, for statin-treated adults with elevated triglycerides and high cardiovascular risk. A prescription drug — not a self-directed regimen.

With meals · with food

Oral capsule — purified EPA ethyl ester (icosapent ethyl)

• Prior serious hypersensitivity reaction to evolocumab
• Use only under clinician direction as part of a lipid-management plan

• Statins
• Ezetimibe

• Known hypersensitivity to icosapent ethyl or its components
• Caution with fish/shellfish allergy (limited data)
• Active serious bleeding

• Anticoagulants / antiplatelets (warfarin, DOACs, aspirin, clopidogrel)
• Antiarrhythmic drugs / rate-control agents