Compare Supplements

Side-by-side comparison of 2 supplements

Exe6.0

Exenatide

Limited safety

Sgl8.5

Semaglutide

Limited safety

Evidence

Evidence Score6/10

Studies: 12

Meta-analyses: 3

Evidence Score8.5/10

Studies: 11

Meta-analyses: 2

Dosage & timing

Dosage:

Prescription-only, clinician-directed. Subcutaneous. Byetta (twice-daily): 5 µg before two main meals, escalated to 10 µg after ~1 month. Bydureon (once-weekly extended-release): 2 mg subcutaneously once weekly. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly extended-release injection (Bydureon)

Dosage:

Prescription-only, clinician-titrated. Subcutaneous (Wegovy weight management: escalate to 2.4 mg once weekly; Ozempic diabetes: 0.5-2.0 mg once weekly). Oral (Rybelsus diabetes: 3-14 mg once daily). DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly injection (Ozempic / Wegovy)

What you'll notice

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Modest weight losspositive

Months

❤️ Cardiovascular: neutral primary outcomeneutral

Years

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Substantial weight losspositive

Months (titrated over 16-20 weeks)

❤️ Reduced cardiovascular eventspositive

Months to years

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Severe renal impairment (eGFR <30 mL/min) or end-stage renal disease — exenatide is renally cleared

Drug Interactions:

Sulfonylureas and insulin
Oral medications (general)
Warfarin

Side Effects:

NauseaVomiting / diarrheaInjection-site nodules / induration (once-weekly form)

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to semaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrhea / constipationGallbladder disease (cholelithiasis / cholecystitis)

How they work together

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