Compare Supplements

10 mg once daily, with or without food, alone or added to a statin — under a clinician. A prescription drug; not a self-directed supplement regimen.

Any time

Oral tablet (ezetimibe 10 mg)

Approved dose is 2 g twice daily (4 g/day total) taken with food, under a clinician, for statin-treated adults with elevated triglycerides and high cardiovascular risk. A prescription drug — not a self-directed regimen.

With meals · with food

Oral capsule — purified EPA ethyl ester (icosapent ethyl)

• Active liver disease or unexplained persistent transaminase elevations (when combined with a statin)
• Pregnancy and breastfeeding (especially in combination with a statin)
• Known hypersensitivity to ezetimibe

• Bile-acid sequestrants (cholestyramine, colesevelam)
• Statins
• Cyclosporine

• Known hypersensitivity to icosapent ethyl or its components
• Caution with fish/shellfish allergy (limited data)
• Active serious bleeding

• Anticoagulants / antiplatelets (warfarin, DOACs, aspirin, clopidogrel)
• Antiarrhythmic drugs / rate-control agents