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A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.
Topical cosmetic only. Leave-on glycolic acid is used at roughly 5-15% in lotions/serums (often at low pH), applied to clean skin a few nights per week and building as tolerated; professional peels (20-70%) are applied in-office at intervals. There is no oral, injectable, or systemic dose — it is not ingested. Pair with daily sunscreen. This library does not provide an ingestion protocol.
Evening
Leave-on lotion or serum (≈5-15% glycolic acid)
Topical cosmetic only. Niacinamide is typically formulated at 2-5% in leave-on serums, creams, or gels and applied to clean skin once or twice daily (AM and/or PM). It layers well under sunscreen and with most other actives. There is no oral, injectable, or systemic dose in this cosmetic context — it is not ingested here. This library does not provide an ingestion protocol.
Any time
Leave-on topical serum or cream (2-5% niacinamide)
Throughout
8-12 weeks
8-16 weeks
Throughout
4-12 weeks
2-12 weeks
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