Compare Supplements

Side-by-side comparison of 2 supplements

Gym5.5

Gymnema Sylvestre

Moderate safety

Sgl8.5

Semaglutide

Limited safety

Evidence

Mostly mechanism / observational

Evidence Score5.5/10

Studies: 14

Meta-analyses: 2

Mostly mechanism / observational

Evidence Score8.5/10

Studies: 36

Meta-analyses: 2

Dosage & timing

Dosage:

200-400mg standardized extract (≥25% gymnemic acids) 1-2x daily, or 2-4g dried leaf

Best Time:

With meals · with food (preferred)

Take with food

Form:

Standardized extract (≥25% gymnemic acids)

Dosage:

Prescription-only, clinician-titrated. Subcutaneous (Wegovy weight management: escalate to 2.4 mg once weekly; Ozempic diabetes: 0.5-2.0 mg once weekly). Oral (Rybelsus diabetes: 3-14 mg once daily). DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-weekly injection (Ozempic / Wegovy)

What you'll notice

🩸 Lower blood glucosepositive

8-12 weeks

🍬 Reduced sweet cravingspositive

Immediate-2 weeks

❤️ Improved lipidspositive

8-12 weeks

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Substantial weight losspositive

Months (titrated over 16-20 weeks)

❤️ Reduced cardiovascular eventspositive

Months to years

Safety

Moderate safety

Contraindications:

Use of insulin or sulfonylureas without medical supervision (hypoglycemia risk)

Drug Interactions:

Diabetes medications (insulin, sulfonylureas, metformin)

Side Effects:

Mild GI upsetHypoglycemia (with diabetes meds)

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to semaglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrhea / constipationGallbladder disease (cholelithiasis / cholecystitis)

Works well with

Berberine

complementary

Chromium

complementary

Cinnamon

complementary

No synergies listed

How they work together

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