Compare Supplements

Prescription-only and indication-dependent. For fertility preservation / intratesticular-testosterone maintenance on TRT, small studies used ~125-500 IU subcutaneously every other day. For spermatogenesis induction in hypogonadotropic hypogonadism, typically ~1,000-2,500 IU two to three times weekly (often combined with FSH), titrated to response. For female ovulation/oocyte-maturation trigger, a single dose (~5,000-10,000 IU urinary or 250 µg recombinant). No dietary-supplement dose exists.

Any time

Prescription hCG — recombinant (choriogonadotropin alfa) or urinary-derived, by injection

900mg/day standardized extract

With meals · with food

Standardized aqueous extract (high-rosmarinic acid)

• Hormone-sensitive tumors (e.g. prostate, breast) or other androgen/estrogen-dependent conditions
• Known hypersensitivity to hCG
• Use without medical supervision

• Exogenous testosterone / anabolic steroids
• FSH / hMG (menotropins)
• Aromatase inhibitors (e.g. anastrozole)

• Known allergy or hypersensitivity to spearmint or other Lamiaceae family plants (mint, lavender, rosemary)
• Severe gastroesophageal reflux disease (GERD) — spearmint may relax lower esophageal sphincter in some individuals
• Hormone-sensitive conditions where androgen reduction is contraindicated (consult physician)

• Hormonal contraceptives / HRT
• Anti-androgen medications (spironolactone, flutamide, finasteride)
• Iron supplements / iron-containing products