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Prescription-only and indication-dependent. For fertility preservation / intratesticular-testosterone maintenance on TRT, small studies used ~125-500 IU subcutaneously every other day. For spermatogenesis induction in hypogonadotropic hypogonadism, typically ~1,000-2,500 IU two to three times weekly (often combined with FSH), titrated to response. For female ovulation/oocyte-maturation trigger, a single dose (~5,000-10,000 IU urinary or 250 µg recombinant). No dietary-supplement dose exists.

Any time

Prescription hCG — recombinant (choriogonadotropin alfa) or urinary-derived, by injection

Standardized yohimbine ~5-10mg (or ~0.2mg/kg) up to 1-2x daily; start at the lowest dose. Raw yohimbe bark is discouraged due to unpredictable content.

Morning

Standardized yohimbine HCl (known dose)

• Hormone-sensitive tumors (e.g. prostate, breast) or other androgen/estrogen-dependent conditions
• Known hypersensitivity to hCG
• Use without medical supervision

• Exogenous testosterone / anabolic steroids
• FSH / hMG (menotropins)
• Aromatase inhibitors (e.g. anastrozole)

• Hypertension or cardiovascular disease
• Anxiety, panic, or other psychiatric disorders
• Kidney or liver disease

• MAO inhibitors
• SSRIs/SNRIs and other serotonergic/noradrenergic drugs
• Stimulants (caffeine, other sympathomimetics)