Compare Supplements

Side-by-side comparison of 2 supplements

Hat6.0

Hyaluronic Acid (topical)

High safety

Nia6.0

Niacinamide

High safety

Evidence

Evidence Score6/10

Studies: 6

Meta-analyses: 0

Evidence Score6/10

Studies: 7

Meta-analyses: 0

Outcome Grades

Skin hydration & glowC

Reduce wrinkles & fine linesC

Skin hydration & glowC

Reduce wrinkles & fine linesC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

Topical cosmetic only. HA serums are applied to clean, slightly damp skin once or twice daily and sealed with a moisturizer to hold water in (in very dry air, HA applied to dry skin can draw moisture outward). There is no oral, injectable, or systemic dose in this cosmetic context. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on serum with high- and low-molecular-weight HA, sealed with a moisturizer

Dosage:

Topical cosmetic only. Niacinamide is typically formulated at 2-5% in leave-on serums, creams, or gels and applied to clean skin once or twice daily (AM and/or PM). It layers well under sunscreen and with most other actives. There is no oral, injectable, or systemic dose in this cosmetic context — it is not ingested here. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (2-5% niacinamide)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a fillerneutral

Throughout

💧 Improved hydration and surface smoothnesspositive

1-8 weeks

💆 Modest, short-term fine-line softeningpositive

4-8 weeks

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🌗 Reduced hyperpigmentation / more even tonepositive

4-12 weeks

💧 Stronger barrier, less water loss, reduced sallownesspositive

2-12 weeks

Safety

High safety

Contraindications:

For topical (skin) use only in this context — not the injectable filler
Known allergy or sensitivity to the formulation
Application to broken or compromised skin until healed

Drug Interactions:

Other leave-on actives

Side Effects:

Tightness/dryness if applied to dry skin in low humidityRare local irritation

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection (in this cosmetic context)
Known allergy or sensitivity to niacinamide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Pure ascorbic acid (vitamin C) at low pH
Strong leave-on exfoliating actives (AHAs/BHAs, retinoids)

Side Effects:

Mild local irritation or rednessTransient flushing or tingling

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