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Approved dose is 2 g twice daily (4 g/day total) taken with food, under a clinician, for statin-treated adults with elevated triglycerides and high cardiovascular risk. A prescription drug — not a self-directed regimen.

With meals · with food

Oral capsule — purified EPA ethyl ester (icosapent ethyl)

500mg

Morning · with food (preferred)

Nicotinamide Riboside Chloride capsules or powder

• Known hypersensitivity to icosapent ethyl or its components
• Caution with fish/shellfish allergy (limited data)
• Active serious bleeding

• Anticoagulants / antiplatelets (warfarin, DOACs, aspirin, clopidogrel)
• Antiarrhythmic drugs / rate-control agents

• Known hypersensitivity to nicotinamide riboside or niacin derivatives
• Active cancer or cancer history: NAD+ elevation may theoretically support tumor cell metabolism (consult oncologist before use)
• Severe hepatic impairment: high-dose NAD+ precursors may affect liver metabolism

• Chemotherapy agents
• PARP inhibitors (e.g., olaparib, niraparib)
• Alcohol