Compare Supplements

Approved dose is 2 g twice daily (4 g/day total) taken with food, under a clinician, for statin-treated adults with elevated triglycerides and high cardiovascular risk. A prescription drug — not a self-directed regimen.

With meals · with food

Oral capsule — purified EPA ethyl ester (icosapent ethyl)

5–20 mg once daily (up to 40 mg in selected high-risk patients), titrated to LDL/ApoB targets — under a clinician. A prescription drug; not a self-directed supplement regimen.

Any time

Oral tablet (rosuvastatin 5–20 mg)

• Known hypersensitivity to icosapent ethyl or its components
• Caution with fish/shellfish allergy (limited data)
• Active serious bleeding

• Anticoagulants / antiplatelets (warfarin, DOACs, aspirin, clopidogrel)
• Antiarrhythmic drugs / rate-control agents

• Active liver disease or unexplained persistent transaminase elevations
• Pregnancy and breastfeeding
• Known hypersensitivity to rosuvastatin

• Cyclosporine
• Gemfibrozil
• Certain antivirals / protease inhibitors