Compare Supplements

Side-by-side comparison of 2 supplements

Lgn6.0

L-Glutamine

High safety

Lcs5.0

L. casei Shirota

High safety

Evidence

Likely helps

Evidence Score6/10

Studies: 266

Meta-analyses: 2

Mostly mechanism / observational

Evidence Score5/10

Studies: 14

Meta-analyses: 1

Dosage & timing

Dosage:

30g

Best Time:

Any time · with food (preferred)

Can take on empty stomach

Form:

L-Glutamine powder

Dosage:

One 65-100 mL bottle of the fermented milk drink daily, delivering roughly 6.5 x 10^9 to 1 x 10^11 CFU depending on the product. Doses across trials span this whole range with no dose-comparison study to separate them.

Best Time:

Any time

Can take on empty stomach

Form:

Fermented milk drink containing L. casei Shirota (Yakult), 65-100 mL daily

What you'll notice

🩸 Fewer Sickle Cell Pain Crisespositive

Ongoing

🦠 Gut Lining Supportpositive

2-4 weeks

🛡️ Immune Support (Mixed)neutral

2-4 weeks

🚽 Softer, less lumpy stoolspositive

4 weeks

🌀 Reduced self-reported constipation severitypositive

2 weeks

🤧 Fewer upper respiratory infections — in working-age adults onlypositive

2-12 weeks

Safety

High safety

Contraindications:

Cirrhosis / hepatic encephalopathy (glutamine is metabolized to ammonia, which can accumulate)

Drug Interactions:

Lactulose

Side Effects:

BloatingGI discomfort

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Proton pump inhibitors

Side Effects:

Mild digestive upsetBloating or flatulence unchanged

Works well with

complementary

complementary

complementary

complementary

complementary

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