Compare Supplements

Side-by-side comparison of 2 supplements

Lcs5.0

L. casei Shirota

High safety

Lgg6.0

L. rhamnosus GG

High safety

Evidence

Mostly mechanism / observational

Evidence Score5/10

Studies: 14

Meta-analyses: 1

Mostly mechanism / observational

Evidence Score6/10

Studies: 44

Meta-analyses: 8

Dosage & timing

Dosage:

One 65-100 mL bottle of the fermented milk drink daily, delivering roughly 6.5 x 10^9 to 1 x 10^11 CFU depending on the product. Doses across trials span this whole range with no dose-comparison study to separate them.

Best Time:

Any time

Can take on empty stomach

Form:

Fermented milk drink containing L. casei Shirota (Yakult), 65-100 mL daily

Dosage:

10-20 billion CFU (1-2 x 10^10) daily; 10 billion CFU/day is the effective floor

Best Time:

Any time · with food

Take with food

Form:

Capsule standardized to ATCC 53103

What you'll notice

🚽 Softer, less lumpy stoolspositive

4 weeks

🌀 Reduced self-reported constipation severitypositive

2 weeks

🤧 Fewer upper respiratory infections — in working-age adults onlypositive

2-12 weeks

💊 Fewer antibiotic-associated diarrhea episodespositive

During the antibiotic course

🏥 Less hospital-acquired diarrhea in childrenpositive

During hospital stay

🚫 No benefit for treating a stomach bugnegative

n/a

Safety

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Proton pump inhibitors

Side Effects:

Mild digestive upsetBloating or flatulence unchanged

High safety

Contraindications:

Immunocompromise or immunosuppression (transplant, chemotherapy, advanced HIV)
Critical illness / ICU admission
Indwelling central venous catheter

Drug Interactions:

Systemic antibiotics
Immunosuppressants

Side Effects:

Mild gas or bloatingBloodstream infection (bacteremia)

Works well with

Probiotics

complementary

B. lactis

complementary

Saccharomyces boulardii

complementary

Probiotics

complementary

How they work together

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