Compare Supplements

Side-by-side comparison of 2 supplements

Lhe3.0

L. helveticus R0052 + B. longum R0175

High safety

Pro9.0

Probiotics

High safety

Evidence

Mostly mechanism / observational

Evidence Score3/10

Studies: 8

Meta-analyses: 0

Likely helps

Evidence Score9/10

Studies: 3948

Meta-analyses: 28

Dosage & timing

Dosage:

3 x 10^9 CFU daily of the fixed combination (L. helveticus R0052 plus B. longum R0175) — the dose used in the founding trial, the dancer trial and the open-label MDD study. No dose-comparison study exists.

Best Time:

Any time

Can take on empty stomach

Form:

Fixed two-strain sachet or capsule: L. helveticus R0052 plus B. longum R0175 at 3 x 10^9 CFU

Dosage:

20billion CFU

Best Time:

Morning

Take with food

Form:

Capsules with multiple strains

What you'll notice

🌤️ Reduced depression scores in diagnosed MDDpositive

8 weeks

🌀 Less stress-induced abdominal pain and nauseapositive

3 weeks

🚫 No effect in healthy adultsnegative

n/a

🍽️ Improved Digestionpositive

2-4 weeks

🛡️ Immune Supportpositive

4-8 weeks

😊 Mood Support (strain- and population-dependent)positive

4-8 weeks

Safety

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter

Drug Interactions:

Systemic antibiotics
Immunosuppressants

Side Effects:

Mild digestive upset

High safety

Contraindications:

Severely immunocompromised individuals
Central venous catheters
Severe acute pancreatitis

Drug Interactions:

Antibiotics
Immunosuppressants

Side Effects:

Bloating/gasDiarrhea

Works well with

complementary

complementary

complementary

complementary

complementary

How they work together

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