Compare Supplements

Side-by-side comparison of 2 supplements

Lp25.0

L. plantarum 299v

High safety

Lre6.0

L. reuteri DSM 17938

High safety

Evidence

Mostly mechanism / observational

Evidence Score5/10

Studies: 16

Meta-analyses: 2

Mostly mechanism / observational

Evidence Score6/10

Studies: 57

Meta-analyses: 5

Outcome Verdicts

Improve digestionToo few graded studies

Improve digestionLimited support

Plain-language verdict per shared outcome, pooled from the studies behind each supplement. Shows which one the evidence backs for the same goal.

Pooled effect-size head-to-headBeta

Direct side-by-side from the meta-analysis. Each row is an outcome where ≥2 of your selected supplements have pooled data. Best effect per row highlighted.

Outcome	L. plantarum 299v	L. reuteri DSM 17938
Improve digestion — Ibs Severity − better · IBS-SSS points	−32.6best weak	−37.2 weak · CI ∋ 0

Click an outcome to see the full ranked table on the goal page.

Dosage & timing

Dosage:

1 x 10^9 CFU (1 billion) daily taken WITH the iron-containing meal is sufficient for the iron effect — in the dual-isotope crossover trial 10^9 was significant (28.6% vs 18.5%, p<0.028) while 10^10 was NOT (29.1% vs 20.1%, p=0.080). The freeze-dried capsule and IBS trials used 1 x 10^10 CFU daily, and the pregnancy trial used 1 x 10^10 CFU twice daily (2 x 10^10 CFU/day)

Best Time:

With meals · with food

Take with food

Form:

Freeze-dried capsule standardized to 299v (DSM 9843)

Dosage:

1 x 10^8 CFU daily (5 drops) for infant colic — the dose used in every positive trial

Best Time:

Any time

Can take on empty stomach

Form:

Oil-suspension drops standardized to DSM 17938

What you'll notice

🧲 Better iron absorption from the same mealpositive

Immediate, per meal

🤰 Better iron status in pregnancypositive

12-25 weeks

🌀 IBS pain and bloating relief (low certainty)neutral

4 weeks

🍼 Less crying in colicky breastfed infantspositive

1-3 weeks

🚫 No benefit in formula-fed infantsnegative

n/a

💧 Shorter acute childhood diarrhoeapositive

1-3 days

Safety

High safety

Contraindications:

Immunocompromise or immunosuppression (class-level precaution for live probiotics)
Critical illness or indwelling central venous catheter
Short-bowel syndrome or compromised gut barrier

Drug Interactions:

Oral iron supplements
Systemic antibiotics

Side Effects:

Transient gas or bloating

High safety

Contraindications:

Immunocompromise or immunosuppression
Critical illness
Indwelling central venous catheter

Drug Interactions:

Systemic antibiotics

Side Effects:

Increased fussing in formula-fed infantsBloodstream infection in immunocompromised or critically ill patients

Works well with

Iron

enhances

Vitamin C

complementary

Probiotics

complementary

How they work together

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Outcome

L. plantarum 299v

L. reuteri DSM 17938

Improve digestion — Ibs Severity

− better · IBS-SSS points

−32.6best

weak

−37.2

weak · CI ∋ 0