Compare Supplements

Side-by-side comparison of 2 supplements

Lir7.5

Liraglutide

Limited safety

Tir7.8

Tirzepatide

Limited safety

Evidence

Evidence Score7.5/10

Studies: 12

Meta-analyses: 3

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Dosage & timing

Dosage:

Prescription-only, clinician-titrated, subcutaneous once daily. Diabetes (Victoza): escalate 0.6 → 1.2 → 1.8 mg/day. Weight management (Saxenda): escalate weekly to 3.0 mg/day. DO NOT self-dose.

Best Time:

Any time

Can take on empty stomach

Form:

Subcutaneous once-daily injection (Victoza for diabetes, Saxenda for weight)

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

What you'll notice

🩸 Improved glycemic controlpositive

Weeks to months

⚖️ Moderate weight losspositive

Months (titrated over weeks)

❤️ Reduced cardiovascular eventspositive

Months to years

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

Safety

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Prior serious hypersensitivity to liraglutide or any GLP-1 receptor agonist

Drug Interactions:

Insulin and sulfonylureas
Oral medications (general)
Other GLP-1 receptor agonists

Side Effects:

NauseaVomiting / diarrhea / constipationGallbladder disease (cholelithiasis / cholecystitis)

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

How they work together

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