Compare Supplements

Side-by-side comparison of 2 supplements

Los4.2

Losartan

Limited safety

MtQ5.0

MitoQ

High safety

Evidence

Mostly mechanism / observational

Evidence Score4.2/10

Studies: 7

Meta-analyses: 0

Mostly mechanism / observational

Evidence Score5/10

Studies: 7

Meta-analyses: 0

Dosage & timing

Dosage:

Off-label longevity/muscle-aging use mirrors low antihypertensive dosing (25–100 mg once daily) under a clinician. Not an approved longevity or anti-sarcopenia regimen; blood pressure, kidney function, and potassium should be monitored.

Best Time:

Any time

Can take on empty stomach

Form:

Oral tablet (losartan potassium)

Dosage:

10-20mg daily

Best Time:

Morning

Can take on empty stomach

Form:

Oral capsule (mitoquinol mesylate, 10-20 mg)

What you'll notice

🧠 Stroke / cardiovascular preventionpositive

Months to years

🫘 Diabetic kidney protectionpositive

Years

💪 Muscle repair / anti-atrophy (animal only)positive

Unknown in humans

🩸 Improved Endothelial Functionpositive

Acute to 6 weeks

🫁 Lowered Liver Enzymespositive

4 weeks

🧠 No Effect on Parkinson'sneutral

12 months

Safety

Limited safety

Contraindications:

Pregnancy (fetal harm)
Bilateral renal artery stenosis
Hyperkalemia

Drug Interactions:

Potassium-sparing diuretics / potassium / salt substitutes
NSAIDs
Lithium

Side Effects:

Dizziness / hypotensionHyperkalemiaAngioedema

High safety

Contraindications:

None established at studied doses; consult a clinician if pregnant, nursing, or on the medications below

Drug Interactions:

Blood pressure medications
Anticoagulants (warfarin)

Side Effects:

GI upset / abdominal discomfortHeadache

Works well with

No synergies listed

CoQ10

complementary

Urolithin A

complementary

NMN

complementary

How they work together

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