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Methylfolate

9/10high

Evidence

Evidence Score9/10

Studies: 40+

Meta-analyses: 6

Dosage & Timing

Dosage:

400-800mcg daily

Best Time:

Morning with or without food, Consistent daily timing

Can take on empty stomach

Form:

L-Methylfolate (5-MTHF)

What You'll Notice

😊 Improved Mood70%

2-4 weeks

⚡ Increased Energy65%

1-3 weeks

❤️ Lower Homocysteine80%

4-8 weeks

Safety

high safety rating

Contraindications:

History of bipolar disorder (may trigger mania - start very low)
Seizure disorders (high doses)

Drug Interactions:

Methotrexate
Anti-seizure medications

Side Effects:

Anxiety/irritabilityInsomniaHeadache

Works Well With

B-Complex (Methylated)complementary

L-Methionineenhances

Myo-Inositolcomplementary

Compare Supplements

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

Compare Supplements

Methylfolate

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories