Compare Supplements

Side-by-side comparison of 2 supplements

MVI6.0

Multivitamin

High safety

Orl6.0

Orlistat

Limited safety

Evidence

Probably helps

Evidence Score6/10

Studies: 74

Meta-analyses: 18

Mostly mechanism / observational

Evidence Score6/10

Studies: 12

Meta-analyses: 3

Dosage & timing

Dosage:

1servings/day

Best Time:

With meals · with food

Take with food

Form:

Capsule or softgel

Dosage:

Prescription Xenical: 120 mg three times daily (360 mg/day), taken with or up to 1 hour after each main fat-containing meal. Over-the-counter Alli: 60 mg three times daily (180 mg/day). Skip the dose if a meal is missed or contains no fat. Used alongside a reduced-calorie diet in which fat supplies roughly 30% of energy — a higher-fat meal makes the gastrointestinal side effects markedly worse, not the weight loss better.

Best Time:

With meals · with food

Take with food

Form:

Xenical 120 mg capsule three times daily with meals (prescription)

What you'll notice

🧠 Improved Memory in Older Adultspositive

3-6 months

🛡️ Reduced Infection Riskpositive

4-8 weeks

⚡ Increased Energy Levelspositive

2-6 weeks

⚖️ Modest additional weight losspositive

4–12 weeks to onset; maximal by 6–12 months

🔁 Less weight regain in year twopositive

Year 2 of continuous use

🩸 Reduced incidence of type 2 diabetespositive

Years

Safety

High safety

Contraindications:

Hemochromatosis or iron overload disorders (avoid iron-containing formulations)
Hypervitaminosis A (avoid high-dose vitamin A formulations)
Hypercalcemia (caution with high-dose calcium-containing MVIs)

Drug Interactions:

Warfarin (Coumadin)
Tetracycline antibiotics (doxycycline, minocycline)
Quinolone antibiotics (ciprofloxacin, levofloxacin)

Side Effects:

Nausea and GI upsetBright yellow/orange urine (riboflavinuria)Constipation

Limited safety

Contraindications:

Chronic malabsorption syndrome
Cholestasis
Pregnancy — intentional weight loss is not a therapeutic goal in pregnancy, and orlistat measurably lowers vitamin D and impairs vitamin E and K absorption (McDuffie 2002)

Drug Interactions: