Compare Supplements

Side-by-side comparison of 2 supplements

Nia6.0

Niacinamide

High safety

Pan6.0

Panthenol (provitamin B5)

High safety

Evidence

Evidence Score6/10

Studies: 7

Meta-analyses: 0

Evidence Score6/10

Studies: 6

Meta-analyses: 0

Outcome Grades

Skin hydration & glowC

A-F grade per outcome, combining overall evidence with goal-specific relevance. A = strong evidence; F = insufficient. Hover a badge for details.

Dosage & timing

Dosage:

Topical cosmetic only. Niacinamide is typically formulated at 2-5% in leave-on serums, creams, or gels and applied to clean skin once or twice daily (AM and/or PM). It layers well under sunscreen and with most other actives. There is no oral, injectable, or systemic dose in this cosmetic context — it is not ingested here. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on topical serum or cream (2-5% niacinamide)

Dosage:

Topical cosmetic only. Panthenol/dexpanthenol is used at roughly 1-5% in moisturizers, soothing creams, and after-procedure ointments, applied to the skin as directed. There is no oral, injectable, or systemic dose in this context — oral vitamin B5 is separate. This library does not provide an ingestion protocol.

Best Time:

Any time

Can take on empty stomach

Form:

Leave-on moisturizer or soothing/repair cream containing panthenol (≈1-5%)

What you'll notice

ℹ️ Cosmetic, appearance-only — not a health effectneutral

Throughout

🌗 Reduced hyperpigmentation / more even tonepositive

4-12 weeks

💧 Stronger barrier, less water loss, reduced sallownesspositive

2-12 weeks

ℹ️ Cosmetic / barrier ingredient — not the oral vitaminneutral

Throughout

💧 Lower water loss, better hydration, faster barrier repairpositive

1-4 weeks

🩹 Soothing and early wound-healing supportpositive

1-2 weeks

Safety

High safety

Contraindications:

For topical (skin) use only — not for ingestion, not for injection (in this cosmetic context)
Known allergy or sensitivity to niacinamide or formulation excipients
Application to broken, irritated, or compromised skin until healed

Drug Interactions:

Pure ascorbic acid (vitamin C) at low pH
Strong leave-on exfoliating actives (AHAs/BHAs, retinoids)

Side Effects:

Mild local irritation or rednessTransient flushing or tingling

High safety

Contraindications:

For topical (skin) use only — not for ingestion in this context
Known allergy or sensitivity to panthenol/dexpanthenol or formulation excipients

Drug Interactions:

Other leave-on actives

Side Effects:

Allergic contact dermatitis

How they work together

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