Compare Supplements

Side-by-side comparison of 2 supplements

Ppo7.0

Peppermint Oil

High safety

Tir7.8

Tirzepatide

Limited safety

Evidence

Evidence Score7/10

Studies: 5

Meta-analyses: 3

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Dosage & timing

Dosage:

180-225mg enteric-coated peppermint oil, 2-3 times daily before meals

Best Time:

Between meals

Can take on empty stomach

Form:

Enteric-coated capsules

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

What you'll notice

✅ IBS symptom reliefpositive

Within hours to 4 weeks

🎯 Reduced abdominal pain/spasmpositive

Days to weeks

🔥 Heartburn / refluxnegative

Soon after dosing

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

Safety

High safety

Contraindications:

Severe GERD or hiatal hernia (may worsen reflux)
Known peppermint/menthol allergy
Achlorhydria (enteric coating may dissolve abnormally)

Drug Interactions:

Antacids / proton-pump inhibitors / H2 blockers
Cyclosporine and CYP3A4/CYP2C19 substrates

Side Effects:

Heartburn / refluxPerianal burningBelching / peppermint taste

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

Works well with

Ginger Extract

complementary

Curcumin

complementary

No synergies listed

How they work together

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