Compare Supplements

Prescription-only, clinician-titrated. Subcutaneous injection immediately before major meals. Type 1 diabetes: typically start 15 µg and titrate to 30-60 µg per meal. Type 2 diabetes (on mealtime insulin): typically start 60 µg and titrate to 120 µg per meal. Reduce mealtime insulin (often by ~50%) when starting. DO NOT self-dose.

With meals · with food

Subcutaneous pre-meal injection (Symlin / SymlinPen)

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Any time

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

• Confirmed diagnosis of gastroparesis (slowed gastric emptying would be worsened)
• Hypoglycemia unawareness
• Poor compliance with current insulin regimen or self-monitoring of blood glucose

• Insulin (mealtime / prandial)
• Other glucose-lowering agents (sulfonylureas, etc.)
• Oral medications requiring rapid absorption

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple endocrine neoplasia syndrome type 2 (MEN2)
• History of pancreatitis (use with caution / avoid)

• Oral contraceptives
• Insulin and sulfonylureas
• Oral medications generally